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Nicholas James, Ph.D.

Nick received his Ph.D. in biophysics and biochemistry from the University of Vermont in 2009. After continuing his training in biophysics as a post-doc under David Jameson Ph.D. at UH Manoa, Nick became a junior P.I. and began to lead research on topics ranging from diabetes to cancer using fluorescence based applications. As a biophysicist, Nick is eager to apply fluorescent techniques to probe the mechanisms that drive Parkinson's disease, Alzheimer's disease, and Diabetes pathologies. Nick's lab uses several tools for their research including spectrophotometers, fluorimeters, microscopes (including a 2-photon laser), and genetic engineering. Nick is passionate about science and committed to helping shape excellent scientists.

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Lab Members



Andrew Jones

Andrew is has been the lab manager for the James Lab since 2019 and is contributing mainly on the LRRK2 sub domain projects. He trains visiting students and undergraduates, performs his own bench projects, and maintains the lab. 

Luke Nelson

Luke is a second year Ph.D. student and is interested in biochemical and biophysical assays to characterize SNX proteins and LRRK2 domains. Luke is primarily focused on in vitro assays using chromatography, fluorescence polarization, CD (Circular Dichroism), FCS (Fluorescence Correlation Spectroscopy), and FRET (Förster Resonance Energy Transfer) to study protein kinetics, energy landscapes, binding, and folding.



Jarod Barrett

Jarod is an undergraduate student pursuing his B.S. in Biochemistry at UH and is researching the WD40-Kinase domains of the LRRK2 protein. This domain is responsible for hydrolysis of ATP and phosphorylation of LRRK2's many substrates. Characterizing the enzymatic activity of the WD40-Kinase domain in vitro will contribute to the overall picture of LRRK2's role in disease.



Dave Jameson, Ph.D.

Dave Jameson is a professor at UH Manoa with over 40 years of fluorescence work and pioneering in applied spectroscopy. He received his Ph.D. in biochemistry from the University of Illinois in 1978. He was advised in his graduate and post-doc career by Gregorio Weber, the father of modern fluorescence. Dave has studied various topics including ARC, Dynamic, Botulinum Toxin, and other systems using fluorescence as a metric for kinetics and folding. Dave has been an assistant professor in the Department of Pharmacology at University of Texas Southwestern Medical Center, a professor and chair for the Department of Biochemistry and Biophysics at the University of Hawaii, and is currently a professor in the Cell and Molecular Department at UH Manoa.





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